2,3,4,5-Tetrahydro-7-hydroxy-1H-benzofuro[2,3-c]azepin-1-one

Name	3-Hydroxy-5,6,7,8-tetrahydro-10-oxa-8-aza-benzo[a]azulen-9-one
Synonyms	CID755673 CID 755673 PKD Inhibitor, CID755673 7-hydroxy-2,3,4,5-tetrahydro-[1]benzofuro[2,3-c]azepin-1-one 2,3,4,5-Tetrahydro-7-hydroxy-1H-benzofuro[2,3-c]azepin-1-one 7-Hydroxy-2,3,4,5-tetrahydro-1H-benzofuro[2,3-c]azepin-1-one 3-Hydroxy-5,6,7,8-tetrahydro-10-oxa-8-aza-benzo[a]azulen-9-one CID 755673 2,3,4,5-Tetrahydro-7-hydroxy-1H-benzofuro[2,3-c]azepin-1-one
CAS	521937-07-5
EINECS	604-604-1

Molecular Formula	C12H11NO3
Molar Mass	217.22
Density	1.341±0.06 g/cm3(Predicted)
Melting Point	244-247 °C(Solv: isopropanol (67-63-0); isopropanol (67-63-0))
Boling Point	531.8±38.0 °C(Predicted)
Solubility	DMSO: ≥15mg/mL
Appearance	powder
Color	white to tan
pKa	9.00±0.20(Predicted)
Storage Condition	2-8°C
In vitro study	In LNCaP prostate cancer cells, CID755673 directly inhibits PKD1 activity. In HeLa cells, CID755673 significantly blocked PMA-induced HDAC5 nuclear export and blocked PKD-mediated protein transport. In prostate cancer cells, CID755673 effectively blocks cell migration and invasion and exhibits inhibitory activity on tumor cell proliferation and cell cycle distribution. In addition, CID755673 alters primary human NK cell effector function.
In vivo study	In a rat model of acute pancreatitis, CID755673, by inhibiting PKD/ PKD1, significantly improved the severity of necrosis and pancreatitis.

Hazard Symbols	Xn - Harmful
Risk Codes	R22 - Harmful if swallowed R36 - Irritating to the eyes
Safety Description	26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany	3

Last Update：2024-01-02 23:10:35

biological activity	CID755673 is a pan-PKD1/2/3 inhibitor with cellular activity, the IC50 values were 180 nM, 280nM, and 227 nM, respectively, with approximately 200-fold higher selectivity than the other CAMKs.
Target	TargetValue PKD1 () 180 nM PKD3 () 227 nM PKD2 () 280 nM
Target	Value
PKD1 ()	180 nM
PKD3 ()	227 nM
PKD2 ()	280 nM
in vitro study	in LNCaP prostate cancer cells, CID755673 directly inhibits PKD1 activity. In HeLa cells, CID755673 significantly blocked PMA-induced HDAC5 nuclear export and blocked PKD-mediated protein transport. In prostate cancer cells, CID755673 effectively blocks cell migration and invasion and exhibits inhibitory activity on tumor cell proliferation and cell cycle distribution. In addition, CID755673 alters primary human NK cell effector function.
in vivo study	in a rat model of acute pancreatitis, CID755673, through inhibition of PKD/ PKD1, significantly improve the severity of necrosis and pancreatitis.

Last Update：2024-04-09 15:16:41

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Product Name: Dibenzofuran Impurity 17 Request for quotation
CAS: 521937-07-5
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052

Wechat: 15671228036

Spot supply

Wechat: 18301782025

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2,3,4,5-Tetrahydro-7-hydroxy-1H-benzofuro[2,3-c]azepin-1-one Request for Quotation